Abstract
We report the delivery of a hydrophobic pesticide, thiamethoxam, by water-soluble nanosized cationic dendrimers that contain hydrophobic dendritic polyesters and peripheral amines, demonstrated by DLS, spectral analysis and ITC. The dendrimer-based nanocarrier can efficiently deliver the pesticide into the live cells and largely increase the cytotoxicity of the drug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemistry
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Animals
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Calorimetry
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Dendrimers / chemistry*
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Drug Carriers / chemistry*
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Hydrophobic and Hydrophilic Interactions
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Larva / drug effects
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Lepidoptera / drug effects
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Lepidoptera / growth & development
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Light
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Liver / metabolism
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Liver / pathology
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Nanostructures / chemistry
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Neonicotinoids
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Nitro Compounds / chemistry*
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Nitro Compounds / metabolism
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Nitro Compounds / toxicity
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Oxazines / chemistry*
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Oxazines / metabolism
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Oxazines / toxicity
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Pesticides / chemistry*
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Pesticides / metabolism
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Pesticides / toxicity
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Polyesters / chemistry
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Scattering, Radiation
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Thiamethoxam
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Thiazoles / chemistry*
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Thiazoles / metabolism
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Thiazoles / toxicity
Substances
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Amines
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Dendrimers
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Drug Carriers
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Neonicotinoids
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Nitro Compounds
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Oxazines
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Pesticides
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Polyesters
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Thiazoles
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Thiamethoxam