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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1964 3
1965 1
1966 1
1967 2
1968 5
1969 2
1970 4
1971 1
1972 10
1973 12
1974 6
1975 26
1976 25
1977 16
1978 19
1979 24
1980 28
1981 10
1982 24
1983 20
1984 24
1985 38
1986 29
1987 23
1988 24
1989 27
1990 37
1991 41
1992 37
1993 38
1994 41
1995 31
1996 47
1997 39
1998 39
1999 35
2000 49
2001 41
2002 46
2003 46
2004 49
2005 46
2006 52
2007 38
2008 51
2009 62
2010 56
2011 43
2012 54
2013 82
2014 98
2015 94
2016 102
2017 98
2018 116
2019 114
2020 126
2021 142
2022 125
2023 129
2024 101

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2,542 results

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Page 1
Interaction of G protein coupled receptors and cholesterol.
Gimpl G. Gimpl G. Chem Phys Lipids. 2016 Sep;199:61-73. doi: 10.1016/j.chemphyslip.2016.04.006. Epub 2016 Apr 20. Chem Phys Lipids. 2016. PMID: 27108066 Review.
G protein coupled receptors (GPCRs) form the largest receptor superfamily in eukaryotic cells. ...Not surprisingly, many hydrophobic residues (primarily leucine and isoleucine) were found to be involved in cholesterol binding. In most cases, the rough beta-face of c …
G protein coupled receptors (GPCRs) form the largest receptor superfamily in eukaryotic cells. ...Not surprisingly, many hydrophobic …
Group II intron-like reverse transcriptases function in double-strand break repair.
Park SK, Mohr G, Yao J, Russell R, Lambowitz AM. Park SK, et al. Cell. 2022 Sep 29;185(20):3671-3688.e23. doi: 10.1016/j.cell.2022.08.014. Epub 2022 Sep 15. Cell. 2022. PMID: 36113466 Free PMC article.
We also found that a group II intron RT can function similarly in DNA repair, with reciprocal active-site substitutions showing isoleucine favors MMEJ and alanine favors primer extension in both enzymes. These DNA repair functions utilize conserved structural features of n …
We also found that a group II intron RT can function similarly in DNA repair, with reciprocal active-site substitutions showing isoleucin …
New Radiolabeled Exendin Analogues Show Reduced Renal Retention.
Joosten L, Frielink C, Jansen TJP, Lobeek D, Andreae F, Konijnenberg M, Heskamp S, Gotthardt M, Brom M. Joosten L, et al. Mol Pharm. 2023 Jul 3;20(7):3519-3528. doi: 10.1021/acs.molpharmaceut.3c00117. Epub 2023 Jun 2. Mol Pharm. 2023. PMID: 37265006 Free PMC article.
In vivo biodistribution revealed a significantly lower kidney uptake of [(68)Ga]Ga-NOTA-MI-exendin-4 at 4 h post-injection (p.i.) (34.2 4.2 %IA/g), compared with [(68)Ga]Ga-NOTA-exendin-4 (128 10 %IA/g). Accumulation of [(68)Ga]Ga-NOTA-MI-exendin-4 in the tumor was …
In vivo biodistribution revealed a significantly lower kidney uptake of [(68)Ga]Ga-NOTA-MI-exendin-4 at 4 h post-injection (p.i.) (34.2 4.2 …
Receptor selectivity between the G proteins Galpha(12) and Galpha(13) is defined by a single leucine-to-isoleucine variation.
Mackenzie AE, Quon T, Lin LC, Hauser AS, Jenkins L, Inoue A, Tobin AB, Gloriam DE, Hudson BD, Milligan G. Mackenzie AE, et al. FASEB J. 2019 Apr;33(4):5005-5017. doi: 10.1096/fj.201801956R. Epub 2019 Jan 2. FASEB J. 2019. PMID: 30601679 Free PMC article.
Despite recent advances in structural definition of GPCR-G protein complexes, the basis of receptor selectivity between G proteins remains unclear. ...B., Gloriam, D. E., Hudson, B. D., Milligan, G. Receptor selectivity between the G proteins Galpha(12 …
Despite recent advances in structural definition of GPCR-G protein complexes, the basis of receptor selectivity between G prot …
Serine 3.39 and isoleucine 4.60 are key sites for 5-HT(2A)R-mediated G(s) signaling.
Xie L, Liu X, Yao Y, Tan B, Su R. Xie L, et al. FEBS Lett. 2024 Jul;598(14):1783-1791. doi: 10.1002/1873-3468.14904. Epub 2024 May 16. FEBS Lett. 2024. PMID: 38757247
Certain amino acid sites of 5-HT(2A)R play crucial roles in interacting with various G proteins. Hallucinogens and non-hallucinogens both act on 5-HT(2A)R but mediate different pharmacological effects, possibly due to the coupling of different G proteins. ...Our res …
Certain amino acid sites of 5-HT(2A)R play crucial roles in interacting with various G proteins. Hallucinogens and non-hallucinogens …
Convergent evolution of AUA decoding in bacteria and archaea.
Suzuki T, Numata T. Suzuki T, et al. RNA Biol. 2014;11(12):1586-96. doi: 10.4161/15476286.2014.992281. RNA Biol. 2014. PMID: 25629511 Free PMC article. Review.
Deciphering AUA codons is a difficult task for organisms, because AUA and AUG specify isoleucine (Ile) and methionine (Met), separately. Each of the other purine-ending sense co-don sets (NNR) specifies a single amino acid in the universal genetic code. ...These modificati …
Deciphering AUA codons is a difficult task for organisms, because AUA and AUG specify isoleucine (Ile) and methionine (Met), separate …
Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion-A Review.
Cai W, Calder PC, Cury-Boaventura MF, De Waele E, Jakubowski J, Zaloga G. Cai W, et al. Nutrients. 2018 Jun 15;10(6):776. doi: 10.3390/nu10060776. Nutrients. 2018. PMID: 29914122 Free PMC article. Review.
Intravenous lipid emulsions (ILEs) have been an integral component of parenteral nutrition for more than 50 years. ...At present there is limited evidence to demonstrate a benefit of olive oil-based ILE over other ILEs on glucose metabolism, and few data exist to de …
Intravenous lipid emulsions (ILEs) have been an integral component of parenteral nutrition for more than 50 years. ...At present ther …
Isoleucine requirement of pregnant sows.
Franco DJ, Josephson JK, Moehn S, Pencharz PB, Ball RO. Franco DJ, et al. J Anim Sci. 2013 Aug;91(8):3859-66. doi: 10.2527/jas.2012-6174. Epub 2013 May 8. J Anim Sci. 2013. PMID: 23658325 Clinical Trial.
Daily gain of the 6 sows was similar in early (344 g/d) and late pregnancy (543 g/d). During pregnancy, sow maternal gain was 19.1 4.4 kg and litters of 17.7 0.8 piglets weighed 22.6 0.9 kg at birth. The Ile requirement was 3.6 1.2 g/d (P = 0.001) in early pr …
Daily gain of the 6 sows was similar in early (344 g/d) and late pregnancy (543 g/d). During pregnancy, sow maternal gain was …
Overexpression of ribosome elongation factor G and recycling factor increases L-isoleucine production in Corynebacterium glutamicum.
Zhao J, Hu X, Li Y, Wang X. Zhao J, et al. Appl Microbiol Biotechnol. 2015 Jun;99(11):4795-805. doi: 10.1007/s00253-015-6458-8. Epub 2015 Feb 24. Appl Microbiol Biotechnol. 2015. PMID: 25707863
Reverse transcription polymerase chain reaction analysis showed that transcriptional levels of genes lysC, hom, thrB, ilvA, ilvBN, and ilvE encoding the key enzymes in the biosynthetic pathway of L-isoleucine increased in C. glutamicum IWJ001 when fusA and/or frr were over …
Reverse transcription polymerase chain reaction analysis showed that transcriptional levels of genes lysC, hom, thrB, ilvA, ilvBN, and ilvE …
The influence of monovalent cations on trimeric G protein G(i)1alpha activity in HEK293 cells stably expressing DOR-G(i)1alpha (Cys(351)-Ile(351)) fusion protein.
Vošahlíková M, Svoboda P. Vošahlíková M, et al. Physiol Res. 2011;60(3):541-7. doi: 10.33549/physiolres.932096. Epub 2011 Mar 14. Physiol Res. 2011. PMID: 21401297 Free article.
The effect of monovalent cations on trimeric G protein G(i)1alpha was measured at equimolar concentration of chloride anion in pertussis-toxin (PTX)-treated HEK293 cells stably expressing PTX-insensitive DOR- G(i)1alpha (Cys(351)-Ile(351)) fusion protein by h …
The effect of monovalent cations on trimeric G protein G(i)1alpha was measured at equimolar concentration of chloride anion in …
2,542 results