Continuing Education Activity
Wernicke-Korsakoff syndrome is a condition caused by a deficiency of thiamine or vitamin B1. Patients classically present with a clinical triad of ophthalmoplegia, altered mental status, and ataxia. This activity outlines the evaluation and management of Wernicke-Korsakoff syndrome and explains the role of interprofessional teams in improving care for patients with this condition.
Objectives:
Identify nutritional deficiency of thiamine in the etiology of Wernicke-Korsakoff syndrome.
Describe the epidemiology of Wernicke-Korsakoff syndrome.
Outline the use of thiamine replacement in the management of Wernicke-Korsakoff syndrome.
Summarize the importance of collaboration and communication among the interprofessional team to enhance the delivery of care for patients affected by Wernicke-Korsakoff syndrome.
Access free multiple choice questions on this topic.
Einführung
Wernicke-Korsakoff syndrome is a common complication of a thiamine deficiency that is primarily seen with alcoholics. This syndrome was classically described as a clinical triad consisting of altered mental status (i.e., confusion or dementia), nystagmus (or ophthalmoplegia), and ataxia. However, less than a third of patients present with this complete triad.[1][2][3]
Wernicke-Korsakoff syndrome is a term that encompasses two different syndromes, Wernicke encephalopathy and Korsakoff syndrome. Wernicke encephalopathy is characterized by an acute confusional state with clinical features that are often reversible. While Korsakoff syndrome is characterized by confabulation, memory loss, and gait abnormalities that are often irreversible and results if Wernicke encephalopathy is not treated adequately.[4]
Etiology
The cause of Wernicke-Korsakoff syndrome is a deficiency of thiamine or vitamin B1. Individuals with poor nutrition for any reason are at risk for this disorder. The most common social factor associated with Wernicke-Korsakoff syndrome is chronic alcohol abuse, leading to decreased absorption and utilization of thiamine. However, it is important to note that there are nonalcoholic causes of thiamine deficiency, which can also produce Wernicke-Korsakoff syndrome. [5][6][7] These include individuals with malnutrition, starvation, schizophrenia, anorexia nervosa, prisoners of war, and terminal malignancies. In the past, baby formula, which was deficient in thiamine, also led to Wernicke-Korsakoff syndrome. Wernicke-Korsakoff syndrome also can develop during the first trimester of pregnancy in women who develop hyperemesis gravidarum. Another common cause is bariatric surgery and malignancies of the gastrointestinal (GI) tract.
Other common causes of Wernicke Korsakoff syndrome include:
Eating disorders (anorexia)
Terminal cancer
Starvation
Strict diets
Inflammatory bowel disease
Bowel obstruction
AIDS
Breastfeeding without supplements
Systemic disorders like tuberculosis, uremia, etc
Epidemiology
The prevalence is between 0 and 2% worldwide. Specific subpopulations have higher prevalence rates, including people who are homeless, older individuals living alone or in isolation, and psychiatric inpatients. Interestingly, prevalence is not connected to alcohol consumption per capita. For example, in France, a country that is well known for its consumption of wine, the prevalence is approximately 0.4%, while Australia has a prevalence of approximately 3%.[8]
Pathophysiology
Brain atrophy associated with Wernicke-Korsakoff Syndrome occurs most predominantly at the mammillary bodies, though it can also occur in other places, including the dorsomedial thalami, the periaqueductal gray, the walls of the third ventricle, and the tectal plate. This is best visualized by increased signal intensity on T2/FLAIR on MRI. In addition to the damage seen in these areas, there may be damage to the cortex, although this may be due to the direct toxic effects of alcohol as opposed to thiamine deficiency.
The amnesia associated with Wernicke-Korsakoff syndrome is a result of atrophy of the structures of the diencephalon (thalamus, hypothalamus, and mammillary bodies) and is similar to amnesia that is present as a result of damage to the medial temporal lobe. It has been argued that the memory impairment can occur as a result of damage along any part of the mammillothalamic tract, which may explain how Wernicke-Korsakoff Syndrome can develop in patients with damage exclusively to either the thalamus or the mammillary bodies.
The ocular motor lesions are due to damage to the abducens nuclei and eye movement centers in the midbrain/pons. Ataxia is due to damage in the superior vermis.
History and Physical
An individual with Wernicke-Korsakoff syndrome classically presents with (1) ocular disturbances which may include diplopia, painless vision loss, or strabismus, (2) gait abnormalities that include a wide-based, short-stepped gait and an inability to stand or ambulate without assistance, and (3) mental status changes that include apathy, a paucity of speech, and indifference to the environment. However, patients commonly do not present with this full triad. As the disorder progresses, other symptoms that may develop include agitation, anger, hallucinations, and confabulations.
Evaluation
The diagnosis of Wernicke-Korsakoff syndrome is made primarily by the history and clinical findings supplemented by labs and imaging. One should maintain a high level of suspicion because of the severe morbidity and mortality that results if treatment is delayed. Prophylactic thiamine administration is relatively safe and should be started even if the diagnosis has not been confirmed. Importantly, thiamine should be administered before glucose to avoid precipitating or exacerbating Wernicke-Korsakoff syndrome.[9][10][11]
Treatment / Management
Unfortunately, it is rare for the individual with Wernicke-Korsakoff syndrome to recover fully even with aggressive treatment. After thiamine treatment, the symptoms of encephalopathy will improve in 5 to 12 days. The patient should be offered oral thiamine and consulted for the rehabilitation and treatment of other comorbid conditions. Most patients with Wernicke-Korsakoff syndrome need long-term care in a chronic care facility. Their prognosis is guarded.[12][13][14][15]
Differential Diagnosis
The differential diagnosis includes the following:
Prognosis
Approximately 25% of patients with Wernicke-Korsakoff syndrome require long-term institutionalization. The patients that depend on long-term care often have one or more comorbidities (somatic and psychiatric).
Mental Status Complications
Global confusion often resolves gradually after treatment.
One in five patients who demonstrate signs of the amnestic state after initiating treatment will have a complete recovery. The remaining patients will have varying degrees of persistent learning and memory impairments.
Maximum recovery may take years and is dependent on abstinence from alcohol.
Ataxic Complications
Approximately half of the patients with ataxic symptoms will recover completely. The other half will have an incomplete recovery, with a residual slow, shuffling, wide-based gait, and the inability to tandem walk.
Vestibular dysfunction improves in about half of all patients.
Ocular Complications
After starting treatment, patients typically recover from Wernicke-Korsakoff syndrome in a predictable pattern. Improvement of ocular abnormalities is the most dramatic, usually occurring within hours after thiamine administration.
If the ocular abnormality does not improve after administrating thiamine, the diagnosis of Wernicke-Korsakoff syndrome should be reevaluated.
Vertical nystagmus may persist for months while the fine horizontal nystagmus can persist indefinitely.
Sixth nerve palsies, ptosis, and vertical-gaze palsies all typically recover completely.
Mortality
Mortality usually occurs secondary to infections and hepatic failure, but some deaths are attributable to defects of prolonged thiamine deficiency.
The mortality rate is 10% to 15% in severe cases.
Prognosis depends on the stage of disease at presentation and time of treatment.
Pearls and Other Issues
Korsakoff syndrome often follows or accompanies Wernicke encephalopathy.
If treated quickly, Korsakoff syndrome development may be prevented with thiamine treatments.
Thiamine needs to be administered quickly in both dose and duration.
Thiamine treatment may result in noticeable improvements in mental status after only 2 to 3 weeks of therapy.
With treatment, Wernicke encephalopathy will not necessarily progress to Wernicke-Korsakoff syndrome.
To reduce the risk of Wernicke-Korsakoff syndrome, limit the intake of alcohol, and ensure that proper nutrition needs are met.
Proper nutrition, in combination with thiamine supplements, may reduce the risk of development of Wernicke-Korsakoff syndrome.
Supplemental thiamine and good nutrition may help heavy drinkers who refuse to or are unable to quit.
Enhancing Healthcare Team Outcomes
Wernicke Korsakoff syndrome is often encountered by the primary care physician, nurse practitioner, or internist. While the diagnosis is relatively simple, the management is unsatisfactory. The disorder is progressive and carries very high morbidity and mortality. The condition is best managed by an interprofessional team that includes a neurologist, mental health nurse, psychiatrist, gastroenterologist, ophthalmologist, and an intensivist. The nurse should assist the clinician in inpatient and family education as the need for education is significant and requires reinforcement. Despite optimal treatment, full recovery does not occur. the majority of patients end up in a long term care facility and have a guarded prognosis.[16]
This research was supported (in whole or in part) by HCA Healthcare and/or an HCA Healthcare affiliated entity. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare of any of its affiliated entities.
References
- 1.
Gerridzen IJ, Joling KJ, Depla MF, Veenhuizen RB, Verschuur EML, Twisk JWR, Hertogh CMPM. Awareness and its relationships with neuropsychiatric symptoms in people with Korsakoff syndrome or other alcohol-related cognitive disorders living in specialized nursing homes.
Int J Geriatr Psychiatry. 2019 Jun;34(6):836-845. [
PMC free article: PMC6593674] [
PubMed: 30854733]
- 2.
Yoon C, Gedzior J, DePry D. Wernicke-Korsakoff syndrome: Focus on low-threshold diagnosis and prompt treatment in the primary care setting.
Int J Psychiatry Med. 2019 May;54(3):172-180. [
PubMed: 30823858]
- 3.
van Dongen LCM, Wingbermühle E, van der Veld WM, Vermeulen K, Bos-Roubos AG, Ockeloen CW, Kleefstra T, Egger JIM. Exploring the behavioral and cognitive phenotype of KBG syndrome.
Genes Brain Behav. 2019 Apr;18(4):e12553. [
PMC free article: PMC6850621] [
PubMed: 30786142]
- 4.
Polegato BF, Pereira AG, Azevedo PS, Costa NA, Zornoff LAM, Paiva SAR, Minicucci MF. Role of Thiamin in Health and Disease.
Nutr Clin Pract. 2019 Aug;34(4):558-564. [
PubMed: 30644592]
- 5.
Doğan İG, Altiokka GU, Türker F, Saka B, Bilgiç B, Orhan EK. Wernicke's Encephalopathy due to Non-Alcoholic Gastrointestinal Tract Disease.
Noro Psikiyatr Ars. 2018 Dec;55(4):307-314. [
PMC free article: PMC6300840] [
PubMed: 30622385]
- 6.
Heirene R, John B, Roderique-Davies G. Identification and Evaluation of Neuropsychological Tools Used in the Assessment of Alcohol-Related Cognitive Impairment: A Systematic Review.
Front Psychol. 2018;9:2618. [
PMC free article: PMC6305333] [
PubMed: 30619013]
- 7.
McGlacken-Byrne D, Wallace E. Vitamin Deficiency and Systemic Failure: The Case For Greater Focus On Wernicke-Korsakoff Syndrome.
Ir Med J. 2018 Dec 06;111(10):848. [
PubMed: 30560643]
- 8.
Arts NJ, Walvoort SJ, Kessels RP. Korsakoff's syndrome: a critical review.
Neuropsychiatr Dis Treat. 2017;13:2875-2890. [
PMC free article: PMC5708199] [
PubMed: 29225466]
- 9.
Nakamura ZM, Tatreau JR, Rosenstein DL, Park EM. Clinical Characteristics and Outcomes Associated With High-Dose Intravenous Thiamine Administration in Patients With Encephalopathy.
Psychosomatics. 2018 Jul-Aug;59(4):379-387. [
PMC free article: PMC6015524] [
PubMed: 29482863]
- 10.
Junghanns K, Wetterling T. [Alcohol withdrawal and its major complications].
Fortschr Neurol Psychiatr. 2017 Mar;85(3):163-177. [
PubMed: 28320026]
- 11.
Latt N, Dore G. Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders.
Intern Med J. 2014 Sep;44(9):911-5. [
PubMed: 25201422]
- 12.
Isenberg-Grzeda E, Chabon B, Nicolson SE. Prescribing thiamine to inpatients with alcohol use disorders: how well are we doing?
J Addict Med. 2014 Jan-Feb;8(1):1-5. [
PubMed: 24343128]
- 13.
Feeney GF, Connor JP. Wernicke-Korsakoff syndrome (WKS) in Australia: no room for complacency.
Drug Alcohol Rev. 2008 Jul;27(4):388-92. [
PubMed: 18584388]
- 14.
Harper C. The neurotoxicity of alcohol.
Hum Exp Toxicol. 2007 Mar;26(3):251-7. [
PubMed: 17439928]
- 15.
Day E, Bentham P, Callaghan R, Kuruvilla T, George S. Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse.
Cochrane Database Syst Rev. 2004;(1):CD004033. [
PubMed: 14974055]
- 16.
Sanvisens A, Zuluaga P, Fuster D, Rivas I, Tor J, Marcos M, Chamorro AJ, Muga R. Long-Term Mortality of Patients with an Alcohol-Related Wernicke-Korsakoff Syndrome.
Alcohol Alcohol. 2017 Jul 01;52(4):466-471. [
PubMed: 28340112]
Disclosure: Shweta Akhouri declares no relevant financial relationships with ineligible companies.
Disclosure: James Kuhn declares no relevant financial relationships with ineligible companies.
Disclosure: Edward Newton declares no relevant financial relationships with ineligible companies.
