The Toll-receptor family and control of innate immunity

Curr Opin Immunol. 1999 Feb;11(1):13-8. doi: 10.1016/s0952-7915(99)80003-x.

Abstract

Innate immune recognition is mediated by a system of germline-encoded receptors that recognize conserved molecular patterns that are associated with microbial pathogens. These receptors are coupled to signal transduction pathways that control expression of a variety of inducible immune-response genes. Toll receptors and the associated signaling pathways of nuclear factor kappaB may represent the most ancient host defense system found in mammals, insects and plants.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila Proteins*
  • Humans
  • Immunity, Innate / physiology*
  • Insect Proteins / immunology
  • Insect Proteins / metabolism
  • Membrane Glycoproteins / immunology
  • Membrane Glycoproteins / metabolism
  • Membrane Glycoproteins / physiology*
  • Membrane Proteins / immunology
  • Membrane Proteins / metabolism
  • NF-kappa B / immunology
  • NF-kappa B / metabolism
  • Receptors, Cell Surface / physiology*
  • Receptors, Immunologic*
  • Signal Transduction
  • Toll-Like Receptors

Substances

  • Drosophila Proteins
  • Insect Proteins
  • Membrane Glycoproteins
  • Membrane Proteins
  • NF-kappa B
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • Tl protein, Drosophila
  • Toll-Like Receptors