Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subarachnoid hemorrhage

Neurol Med Chir (Tokyo). 1998 Dec;38(12):805-10; discussion 810-1. doi: 10.2176/nmc.38.805.

Abstract

Fasudil hydrochloride is a new type of intracellular calcium antagonist, different from the calcium entry blockers that are commonly employed for clinical use. Since September 1995, the combination of fasudil hydrochloride and ozagrel sodium, an inhibitor of thromboxane A2 synthesis, has been used to treat 60 patients at risk of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. The effectiveness of this combination therapy was investigated by comparison with the outcome of 57 patients previously treated with only ozagrel sodium. The combination therapy was significantly more effective (p < 0.01) in reducing the incidence of low density areas on computed tomography scans, and reduced, but not significantly, the occurrence of symptomatic vasospasm. The combination therapy of fasudil hydrochloride and ozagrel sodium has superior effectiveness over only ozagrel sodium in treating patients at risk of vasospasm after aneurysmal subarachnoid hemorrhage.

Publication types

  • Comparative Study

MeSH terms

  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / adverse effects
  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / analogs & derivatives*
  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / therapeutic use
  • Adult
  • Aged
  • Aneurysm, Ruptured / surgery*
  • Calcium Channel Blockers / adverse effects
  • Calcium Channel Blockers / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Fibrinolytic Agents / adverse effects
  • Fibrinolytic Agents / therapeutic use*
  • Humans
  • Intracranial Aneurysm / surgery*
  • Ischemic Attack, Transient / drug therapy*
  • Male
  • Methacrylates / adverse effects
  • Methacrylates / therapeutic use*
  • Middle Aged
  • Postoperative Complications / drug therapy*
  • Retrospective Studies
  • Subarachnoid Hemorrhage / surgery*
  • Treatment Outcome

Substances

  • Calcium Channel Blockers
  • Fibrinolytic Agents
  • Methacrylates
  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
  • ozagrel
  • fasudil