High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced nephropathia epidemica

M Kanerva; A Vaheri; J Mustonen; J Partanen

doi:10.1080/00365549850161629

High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced nephropathia epidemica

Scand J Infect Dis. 1998;30(5):532-4. doi: 10.1080/00365549850161629.

Authors

M Kanerva¹, A Vaheri, J Mustonen, J Partanen

Affiliation

¹ Haartman Institute, Department of Virology, University of Helsinki, Finland.

PMID: 10066063
DOI: 10.1080/00365549850161629

Abstract

The biallelic polymorphisms in the tumour necrosis factor-alpha (TNF-alpha) gene promoter region were studied in patients with nephropathia epidemica (NE). The rarer TNF2 allele, associated with a high TNF-alpha producer phenotype, was more frequently found in hospitalized NE patients (42%) than in healthy controls (15%; p=0.0064). The putative role of TNF2 as an independent risk factor for NE is discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Genetic Predisposition to Disease
HLA Antigens / genetics*
Hantavirus Infections / genetics*
Haplotypes
Humans
Major Histocompatibility Complex / genetics
Orthohantavirus
Phenotype
Polymerase Chain Reaction
Polymorphism, Genetic
Risk Factors
Tumor Necrosis Factor-alpha / genetics*

Substances

HLA Antigens
Tumor Necrosis Factor-alpha