Reference typing report for complement receptor 1 (CR1)

Exp Clin Immunogenet. 1998;15(4):291-4. doi: 10.1159/000019084.

Abstract

A total of 100 Chinese blood donors (50 from Shen-Zhen and 50 from Taiwan) were studied by the participants in addition to 9 reference samples. A new nomenclature for the CR1 structural alleles was recommended by the participants which would use a numbering system, e.g. CR1*1. The structural allele frequencies in the Chinese were: CR1*1 (190 kD) 0.96, CR1*2 (220 kD) 0.03, CR1*3 (160 kD) 0.01 and CR1*4 (250 kD) 0.00. The HindIII expression polymorphism was also studied and the high expressing allele had a gene frequency of 0.71 while the low expressor gene frequency was 0.28. Erythrocyte copy numbers were quantified and compared between laboratories with good correlation (R = 0.55-0.88). The mean (+/- SD) erythrocyte copy number was 463 (+/- 229) in the Taiwan donors and 446 (+/- 207) in the Mainland Chinese.

Publication types

  • Congress

MeSH terms

  • Alleles
  • China
  • Erythrocytes / immunology
  • Gene Amplification
  • Gene Frequency
  • Humans
  • Receptors, Complement 3b / blood
  • Receptors, Complement 3b / classification*
  • Receptors, Complement 3b / genetics*
  • Reference Standards
  • Taiwan
  • Terminology as Topic

Substances

  • Receptors, Complement 3b