Abstract
Two new jaspamide derivatives (1 and 2) along with jaspamide have been isolated from the marine sponge Jaspis splendans collected in Vanuatu. Their chemical structures were determined from 1D and 2D NMR studies and MS data. These two compounds inhibited the in vitro growth of the NSCLC-N6 human tumor cell lines with IC50 values in the microg/mL range.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification*
-
Antineoplastic Agents / pharmacology
-
Carcinoma, Non-Small-Cell Lung / pathology
-
Cell Division / drug effects
-
Drug Screening Assays, Antitumor
-
Humans
-
Lung Neoplasms / pathology
-
Molecular Structure
-
Peptides, Cyclic / chemistry
-
Peptides, Cyclic / isolation & purification*
-
Peptides, Cyclic / pharmacology
-
Porifera / chemistry*
-
Spectrum Analysis
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents
-
Peptides, Cyclic
-
jaspamide B
-
jaspamide C