Abstract
A convenient approach to the functionalization of peptides with the macrocyclic 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA) moiety has been developed. Protected components (using tert-butyl or tert-butyloxycarbonyl groups) of both the peptide and the chelate were assembled on the same solid resin support. Deprotection and cleavage of the resin-bound DOTA-peptides were performed in one step using a trifluoroacetic acid cleavage mixture to yield free DOTA-peptide amides.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Chelating Agents
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Chromatography, High Pressure Liquid
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Heterocyclic Compounds, 1-Ring*
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Indicators and Reagents
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Molecular Sequence Data
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Oligopeptides / chemical synthesis*
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Oligopeptides / chemistry
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Oligopeptides / pharmacokinetics
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Peptides / chemical synthesis*
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Peptides / chemistry
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Peptides / pharmacokinetics
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Radioimmunotherapy / methods
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Resins, Plant
Substances
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Chelating Agents
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Heterocyclic Compounds, 1-Ring
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Indicators and Reagents
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Oligopeptides
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Peptides
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Resins, Plant
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1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid