Abstract
Using measurements of QT/RR slopes with a computerized Holter system, QT interval dynamicity was evaluated in 19 patients with normal structural heart before and 2 months after oral treatment with verapamil prescribed for paroxysmal atrioventricular nodal reentrant tachycardia. Verapamil significantly shortened QT at low heart rates, mainly in the diurnal period, and this characteristic may explain, in part, the previously reported protective effect of verapamil against torsades de pointes.
MeSH terms
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Administration, Oral
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Adult
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Aged
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Anti-Arrhythmia Agents / administration & dosage
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Anti-Arrhythmia Agents / therapeutic use*
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Circadian Rhythm
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Electrocardiography, Ambulatory / drug effects*
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Female
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Heart Rate / drug effects
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Humans
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Male
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Middle Aged
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Tachycardia, Atrioventricular Nodal Reentry / drug therapy
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Tachycardia, Paroxysmal / drug therapy
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Torsades de Pointes / drug therapy
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Verapamil / administration & dosage
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Verapamil / therapeutic use*
Substances
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Anti-Arrhythmia Agents
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Verapamil