Phenotypic and genotypic investigations of a healthy volunteer deficient in the conversion of losartan to its active metabolite E-3174

Clin Pharmacol Ther. 1999 Mar;65(3):348-52. doi: 10.1016/S0009-9236(99)70114-1.
No abstract available

Publication types

  • Case Reports
  • Clinical Conference
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Anti-Arrhythmia Agents / metabolism*
  • Antihypertensive Agents / metabolism*
  • Aryl Hydrocarbon Hydroxylases*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / genetics*
  • Genotype
  • Humans
  • Imidazoles / metabolism*
  • Losartan / metabolism*
  • Male
  • Mixed Function Oxygenases / genetics*
  • Phenotype
  • Reference Values
  • Steroid 16-alpha-Hydroxylase*
  • Steroid Hydroxylases / genetics*
  • Tetrazoles / metabolism*
  • Volunteers

Substances

  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Imidazoles
  • Tetrazoles
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Steroid Hydroxylases
  • Aryl Hydrocarbon Hydroxylases
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A
  • Steroid 16-alpha-Hydroxylase
  • losartan carboxylic acid
  • Losartan