Identification and biosynthetic origins of sterols in the marine bryozoan bugula neritina

RG Kerr; R Vicchiarelli; SS Kerr

doi:10.1021/np9804740

Identification and biosynthetic origins of sterols in the marine bryozoan bugula neritina

J Nat Prod. 1999 Mar;62(3):468-70. doi: 10.1021/np9804740.

Authors

RG Kerr¹, R Vicchiarelli, SS Kerr

Affiliation

¹ Department of Chemistry and Biochemistry, Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, Florida 33431-0991, USA.

PMID: 10096860
DOI: 10.1021/np9804740

Abstract

The sterols of Bugula neritina have been isolated and characterized spectroscopically. Cholesterol was found to be the predominant sterol with C28, C29, and C30 sterols recovered as minor components. In vivo biosynthetic experiments revealed that cholesterol is the only sterol produced by de novo biosynthesis, indicating that the other sterols are of dietary origin. Further, biosynthetic experiments using in vitro techniques indicated that 24-alkylated sterols (4, 5, 7, and 8) are produced by alkylation of dietary sterols, while others are exclusively of dietary origin.