Abstract
The effect of interferon (IFN)beta-1a and IFNbeta-1b on human myelin basic protein-reactive T-cell lines was investigated. Both drugs inhibited proliferation and production of lymphotoxin (LT), whereas the production of interleukin-4 was not altered and interleukin-10 was induced. Comparing equal numbers of units IFNbeta-1a and -1b showed almost identical results. These in vitro data indicate that the immunomodulatory capacity of both interferons with respect to T cells paralleled their antiviral effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Cell Line / drug effects
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Cell Line / immunology
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Cytokines / biosynthesis
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Humans
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Interferon beta-1a
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Interferon beta-1b
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Interferon-beta / immunology*
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Interferon-beta / pharmacology
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Lymphocyte Activation / immunology
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Models, Immunological
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Myelin Basic Protein / drug effects*
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology*
Substances
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Cytokines
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Myelin Basic Protein
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Interferon beta-1b
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Interferon-beta
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Interferon beta-1a