Abstract
The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / pharmacology*
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Antitubercular Agents / pharmacology*
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Drug Resistance, Multiple
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Drug Synergism
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Humans
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Isoniazid / pharmacology*
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Melatonin / pharmacology*
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / cytology
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Mycobacterium tuberculosis / drug effects*
Substances
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Antioxidants
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Antitubercular Agents
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Melatonin
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Isoniazid