Abstract
Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect, leading to the identification of a previously undescribed role for E4 gene products in resistance to cytolysis.
MeSH terms
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Adenovirus E3 Proteins / immunology
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Adenovirus E4 Proteins / genetics
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Adenovirus E4 Proteins / immunology*
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Adenoviruses, Human / immunology*
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Animals
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Female
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Genetic Vectors / immunology*
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Humans
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Interferon-gamma / immunology
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Interferon-gamma / pharmacology
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Adenovirus E3 Proteins
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Adenovirus E4 Proteins
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Interferon-gamma