Abstract
The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear localization of proteins is determined by their ability to interact with specific nuclear import and export factors. In the past year, substrate phosphorylation has emerged as a common mechanism for controlling this interaction.
MeSH terms
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Biological Transport / physiology*
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Cell Compartmentation
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Cell Cycle / physiology
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Cell Nucleus / metabolism*
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Energy Metabolism
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Eukaryotic Cells / cytology
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Eukaryotic Cells / metabolism
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Eukaryotic Cells / ultrastructure
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Fungal Proteins / physiology
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Gene Expression Regulation
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Humans
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Models, Biological
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Nuclear Proteins / metabolism
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Phosphorylation
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Protein Processing, Post-Translational / physiology
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Saccharomyces cerevisiae / cytology
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Saccharomyces cerevisiae / physiology
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Signal Transduction / physiology
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Stress, Physiological / genetics
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Stress, Physiological / physiopathology
Substances
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Fungal Proteins
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Nuclear Proteins