Abstract
During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and the T cell receptor at the cellular and molecular levels is just beginning to be achieved.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Abatacept
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Animals
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Antigen Presentation
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Antigens, CD / immunology
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Antigens, Differentiation / immunology*
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B7-1 Antigen / immunology
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B7-2 Antigen
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CD28 Antigens / immunology*
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CTLA-4 Antigen
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Humans
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Immunoconjugates*
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Lymphocyte Activation*
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Lymphokines / metabolism
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Membrane Glycoproteins / immunology
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Mice
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Models, Immunological
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Receptor-CD3 Complex, Antigen, T-Cell / immunology
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Receptors, Antigen, T-Cell / immunology*
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Signal Transduction / physiology*
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
Substances
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Antigens, CD
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Antigens, Differentiation
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B7-1 Antigen
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B7-2 Antigen
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CD28 Antigens
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CD86 protein, human
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CTLA-4 Antigen
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CTLA4 protein, human
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Cd86 protein, mouse
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Ctla4 protein, mouse
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Immunoconjugates
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Lymphokines
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Membrane Glycoproteins
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Receptor-CD3 Complex, Antigen, T-Cell
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Receptors, Antigen, T-Cell
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Abatacept