Abstract
Three C46 (1-3) and three C30 (4-6) polyacetylenic alcohols with cytotoxic activity against a small panel of human solid-tumor cell lines have been isolated from the marine sponge Petrosia sp. Although compound 1 was identified as the stereoisomer of petrocortyne A, the structures of compounds 2-5 have not been previously reported and were established by spectral methods. Compound 6 was identified as the known compound petrosiacetylene D. The stereochemistry of compounds 1-5 was determined by the modified Mosher's method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylene / analogs & derivatives*
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Acetylene / isolation & purification
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Acetylene / pharmacology
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Animals
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Artemia
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Humans
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Lethal Dose 50
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Polymers / isolation & purification
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Polymers / pharmacology*
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Polyynes
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Porifera / chemistry*
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Polymers
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Polyynes
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Acetylene