Abstract
Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute viral encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspects of virus-induced neuronal apoptosis that remain to be discovered.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis* / physiology
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Cell Death / physiology
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Central Nervous System Infections / pathology
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Central Nervous System Infections / physiopathology
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Central Nervous System Infections / virology*
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Neurons / cytology*
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Neurons / physiology
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Neurons / virology*
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Signal Transduction
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Virus Diseases / pathology
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Virus Diseases / physiopathology*