Endocytosis: How dynamin sets vesicles PHree!

Curr Biol. 1999 Apr 22;9(8):R301-4. doi: 10.1016/s0960-9822(99)80184-5.

Abstract

The dynamin GTPase is required for clathrin-dependent, receptor-mediated endocytosis. Exciting new studies have shown that dynamin's pleckstrin homology domain binds to phosphatidylinositol 4, 5-bisphosphate in vivo, thus localising dynamin directly at the plasma membrane and ultimately enabling vesiculation.

Publication types

  • Review

MeSH terms

  • Binding Sites
  • Blood Proteins / metabolism
  • Cytoplasmic Granules
  • Dimerization
  • Dynamins
  • Endocytosis / physiology*
  • GTP Phosphohydrolases / chemistry
  • GTP Phosphohydrolases / metabolism
  • Intracellular Membranes
  • Phosphoproteins*

Substances

  • Blood Proteins
  • Phosphoproteins
  • platelet protein P47
  • GTP Phosphohydrolases
  • Dynamins