Synthesis and evaluation of antimycobacterial activity of 4-phenyl-1,8-naphthyridine derivatives

Farmaco. 1998 Dec 30;53(12):741-6. doi: 10.1016/s0014-827x(98)00094-9.

Abstract

Some 4-phenyl-1,8-naphthyridine derivatives with a piperazino group in the 2- and/or 7-position have been synthesized and evaluated for their tuberculostatic activity. The compounds 1, 6, 10, 17b,c and 19i showed a marked activity against Mycobacterium tuberculosis H37Rv. For this series of compounds, submitted to biological screening, no structure-activity relationship can be deduced.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemical synthesis*
  • Antitubercular Agents / pharmacology
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects*
  • Naphthyridines / chemical synthesis*
  • Naphthyridines / pharmacology

Substances

  • Antitubercular Agents
  • Naphthyridines