[Effect of Soviet-made prostaglandin E1 on the aggregation of thrombocytes and erythrocytes]

K M Lakin; V A Makarov; M S Ovnatanova; I S Azhgikhin

[Effect of Soviet-made prostaglandin E1 on the aggregation of thrombocytes and erythrocytes]

Farmakol Toksikol. 1976 Jun-Aug;39(4):436-40.

[Article in Russian]

Authors

K M Lakin, V A Makarov, M S Ovnatanova, I S Azhgikhin

PMID: 1027569

Abstract

The effect of prostaglandin E1 in a concentration of 0.1 gamma/ml on the aggregation and disaggregation of thrombocytes and erythrocytes in vitro was studied. Prostaglandin E1 was found to materially reduce the aggregation and to produce disaggregation of thrombocytes. A somewhat diminished aggregation of erythrocytes was also noted. Prostaglandin E1 failed to cause disaggregation of erythrocytes.

Publication types

English Abstract

MeSH terms

Adenosine Diphosphate / antagonists & inhibitors
Adenosine Diphosphate / pharmacology
Animals
Drug Antagonism
Erythrocyte Aggregation / drug effects*
Female
In Vitro Techniques
Male
Platelet Aggregation / drug effects*
Prostaglandins E / pharmacology*
Rabbits

Substances

Prostaglandins E
Adenosine Diphosphate