Abstract
Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers. The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3.
MeSH terms
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Animals
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Antigens, Neoplasm / chemistry*
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Cancer Vaccines / chemical synthesis*
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Cancer Vaccines / pharmacology*
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Carbohydrate Sequence
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Immunoconjugates / chemistry*
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Immunoconjugates / pharmacology*
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Lipid A / analogs & derivatives*
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Lipid A / chemistry
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Mice
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Mice, Inbred C3H
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Molecular Sequence Data
Substances
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Antigens, Neoplasm
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Cancer Vaccines
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Immunoconjugates
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Lipid A