Abstract
Using 18F-fluorodeoxyglucose and 11C-diprenorphine positron emission tomography (PET), we investigated alterations in glucose metabolism and opioid receptor binding in a patient with central poststroke pain, which developed after a small pontine hemorrhagic infarction. In comparison with normal databases, reduced 11C-diprenorphine binding was more accentuated than the hypometabolism on the lateral cortical surface contralateral to the symptoms, and a differential abnormal distribution between the tracers was seen in pain-related central structures. These results show that 11C-diprenorphine PET provides unique information for the understanding of central poststroke pain.
Publication types
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Case Reports
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Carbon Radioisotopes*
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Cerebral Hemorrhage / complications
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Cerebral Infarction / complications*
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Cerebral Infarction / metabolism
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Cerebrovascular Disorders / complications
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Cerebrovascular Disorders / metabolism
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Diprenorphine* / pharmacology
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Fluorodeoxyglucose F18
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Glucose / metabolism
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Humans
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Male
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Middle Aged
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Narcotic Antagonists* / pharmacology
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Pain / etiology*
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Pain / metabolism
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Pons / blood supply*
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Pons / diagnostic imaging
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Radiopharmaceuticals*
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Receptors, Opioid / metabolism*
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Sensation Disorders / etiology*
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Sensation Disorders / metabolism
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Tomography, Emission-Computed*
Substances
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Carbon Radioisotopes
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Narcotic Antagonists
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Radiopharmaceuticals
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Receptors, Opioid
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Fluorodeoxyglucose F18
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Diprenorphine
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Glucose