Amyloid beta precursor protein-mRNA is expressed throughout cerebral vessel walls

Brain Res. 1999 May 15;828(1-2):179-83. doi: 10.1016/s0006-8993(99)01361-x.

Abstract

To determine the presence and distribution of cerebrovascular Abeta production we investigated amyloid beta precursor protein (AbetaPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, AbetaPP-mRNA was expressed in endothelial cells, smooth muscle cells, adventitial cells and brain pericytes and/or perivascular cells. Meningeal cells also expressed AbetaPP-mRNA. AbetaPP was detected in endothelial cells, smooth muscle cells and adventitial cells. The demonstration of AbetaPP-mRNA at all vascular sites where amyloid formation can occur supports an important contribution of locally derived Abeta to cerebrovascular amyloidosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism
  • Amyloid beta-Protein Precursor / genetics*
  • Brain / blood supply
  • Brain / metabolism
  • Cerebral Amyloid Angiopathy / genetics*
  • Cerebral Amyloid Angiopathy / metabolism
  • Cerebral Angiography
  • Cerebral Arteries / chemistry
  • Cerebral Arteries / physiology
  • Cerebral Hemorrhage / genetics*
  • Cerebral Hemorrhage / metabolism
  • Gene Expression
  • Humans
  • In Situ Hybridization
  • Middle Aged
  • RNA, Messenger / analysis

Substances

  • Amyloid beta-Protein Precursor
  • RNA, Messenger