Abstract
The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-Otetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 microg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology*
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Dose-Response Relationship, Drug
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Drug Interactions
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Ear, External / drug effects
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Ear, External / enzymology
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Ear, External / pathology
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Edema / chemically induced
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Edema / pathology
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Epidermal Growth Factor / pharmacology*
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Female
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Humans
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Inflammation / chemically induced*
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Inflammation / pathology
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Mice
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Models, Biological
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Peroxidase / drug effects
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Peroxidase / metabolism*
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Psoriasis / pathology
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Recombinant Proteins / pharmacology
Substances
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Anti-Inflammatory Agents
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Recombinant Proteins
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Epidermal Growth Factor
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Peroxidase