Additional reduction in blood pressure after cholesterol-lowering treatment by statins (lovastatin or pravastatin) in hypercholesterolemic patients using angiotensin-converting enzyme inhibitors (enalapril or lisinopril)

Am J Cardiol. 1999 May 15;83(10):1497-9, A8. doi: 10.1016/s0002-9149(99)00132-0.

Abstract

Blood pressure (BP) reduction was compared between patients receiving angiotensin-converting enzyme inhibitors alone and patients receiving these medications plus statins after 3 months of dietary intervention. Although BP was similarly reduced at week 4, the statin-treated group had a greater reduction in BP and total cholesterol levels at week 16, suggesting a synergistic effect between cholesterol lowering with statins and angiotensin-converting enzyme inhibitor treatment for hypertensive patients.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Anticholesteremic Agents / therapeutic use*
  • Blood Pressure / drug effects*
  • Drug Interactions
  • Enalapril / therapeutic use*
  • Female
  • Heart Rate / drug effects
  • Humans
  • Hypercholesterolemia / complications
  • Hypercholesterolemia / drug therapy*
  • Hypertension / complications
  • Lisinopril / therapeutic use*
  • Lovastatin / therapeutic use*
  • Male
  • Middle Aged
  • Pravastatin / therapeutic use*

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Anticholesteremic Agents
  • Enalapril
  • Lovastatin
  • Lisinopril
  • Pravastatin