Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors

Infect Dis Clin North Am. 1999 Jun;13(2):341-53, vii. doi: 10.1016/s0891-5520(05)70078-7.

Abstract

The ability of a host to sense invasion by a pathogenic organism, and to respond appropriately to control infection, is paramount to survival. To that end, an array of receptors and binding proteins has evolved as part of the innate immune system to detect Gram-negative bacteria. This article reviews the role of CD14, other LPS binding proteins, and the Toll family of receptors in the innate recognition of bacterial lipopolysaccharide.

Publication types

  • Review

MeSH terms

  • Animals
  • CD11 Antigens / physiology
  • CD18 Antigens / physiology
  • Drosophila Proteins*
  • Endotoxins / antagonists & inhibitors
  • Humans
  • Lipid A / pharmacology
  • Lipopolysaccharide Receptors / metabolism
  • Lipopolysaccharide Receptors / pharmacology
  • Lipopolysaccharide Receptors / physiology*
  • Lipopolysaccharides / antagonists & inhibitors
  • Lipopolysaccharides / toxicity*
  • Membrane Glycoproteins / physiology
  • Mice
  • Mice, Knockout / genetics
  • Receptors, Cell Surface / physiology
  • Shock, Septic / etiology
  • Signal Transduction
  • Toll-Like Receptors

Substances

  • CD11 Antigens
  • CD18 Antigens
  • Drosophila Proteins
  • Endotoxins
  • Lipid A
  • Lipopolysaccharide Receptors
  • Lipopolysaccharides
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors