In lizards, information from the various senses is relayed to the hypothalamus via the cortico-septo-hypothalamic pathway. It appears that the anatomical organization of the incoming fibres in the medial cortex differs considerably between the various lizard species. In the present account it is shown that it is the location of the termination of the incoming fibres in the medial cortex that determines what kind of sensory information will reach the hypothalamic centres that are responsible for sexual and feeding behaviour.