A cyclitol derivative as a replication inhibitor from the marine sponge Petrosia sp

J Nat Prod. 1999 May;62(5):773-6. doi: 10.1021/np9804785.

Abstract

A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2',3',4',5'-tetrahydroxycyclopentyl)-3-O-(10' '-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA Replication / drug effects*
  • DNA, Viral / metabolism
  • Glycerol / analogs & derivatives*
  • Glycerol / chemistry
  • Glycerol / isolation & purification
  • Glycerol / pharmacology
  • Magnetic Resonance Spectroscopy
  • Nucleic Acid Synthesis Inhibitors / chemical synthesis*
  • Nucleic Acid Synthesis Inhibitors / chemistry
  • Nucleic Acid Synthesis Inhibitors / pharmacology
  • Porifera / chemistry*
  • Simian virus 40 / metabolism
  • Spectrometry, Mass, Fast Atom Bombardment
  • Sugar Alcohols / chemistry
  • Sugar Alcohols / isolation & purification
  • Sugar Alcohols / pharmacology*
  • Topoisomerase I Inhibitors

Substances

  • 1-O-(2',3',4',5'-tetrahydroxycyclopentyl)-3-O-(10''-methylhexadecyl)glycerol
  • DNA, Viral
  • Nucleic Acid Synthesis Inhibitors
  • Sugar Alcohols
  • Topoisomerase I Inhibitors
  • Glycerol