Noroudemansin A, a new antifungal antibiotic from Pterula species 82168 and three semisynthetic derivatives

M Engler-Lohr; T Anke; V Hellwig; W Steglich

doi:10.1515/znc-1999-3-404

Noroudemansin A, a new antifungal antibiotic from Pterula species 82168 and three semisynthetic derivatives

Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):163-8. doi: 10.1515/znc-1999-3-404.

Authors

M Engler-Lohr¹, T Anke, V Hellwig, W Steglich

Affiliation

¹ Lehrbereich Biotechnologie der Universität, Kaiserslautern, Germany.

PMID: 10349735
DOI: 10.1515/znc-1999-3-404

Abstract

A new antifungal (E)-beta-methoxyacrylate noroudemansin A (1), was isolated from cultures of Pterula sp. 82168. Its biological activities were investigated and compared with oudemansin A. The structure was elucidated by spectroscopic methods. Three semisynthetic noroudemansin A derivatives were synthesized from the natural product.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylates / chemistry
Acrylates / isolation & purification
Acrylates / pharmacology
Animals
Antibiotics, Antineoplastic / chemical synthesis
Antibiotics, Antineoplastic / chemistry*
Antibiotics, Antineoplastic / toxicity
Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry*
Antifungal Agents / pharmacology
Basidiomycota*
Cell Line
Cell Survival / drug effects
Cricetinae
Fungi / drug effects*
HL-60 Cells / drug effects
HeLa Cells
Humans
Leukemia L1210
Mice
Microbial Sensitivity Tests
Molecular Structure
Penicillium / drug effects
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

Acrylates
Antibiotics, Antineoplastic
Antifungal Agents
noroudemansin A