Cutaneous extravascular necrotizing granuloma (Churg Strauss granuloma)

Clin Exp Dermatol. 1999 May;24(3):193-5. doi: 10.1046/j.1365-2230.1999.00452.x.

Abstract

Churg Strauss granuloma (cutaneous extravascular necrotizing granuloma) is a distinct entity which is associated with systemic immunoreactive or autoimmune diseases in a majority of cases. Typically, Churg Strauss granuloma presents as symmetrical papules or nodules on the extremities. There are two histological patterns: the classic pattern reveals palisading granuloma with central degenerated collagen, interspersed polymorphonuclear leukocytes, and leukocytoclastic debris; the focal basophilic necrosis pattern does not show palisading granuloma. We report two cases of Churg Strauss granuloma with different histopathological patterns.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antibodies, Antinuclear / analysis
  • Biopsy
  • Blood Sedimentation
  • Churg-Strauss Syndrome / blood
  • Churg-Strauss Syndrome / drug therapy
  • Churg-Strauss Syndrome / pathology*
  • Collagen / ultrastructure
  • Dapsone / therapeutic use
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neutrophil Infiltration
  • Prednisolone / therapeutic use
  • Rheumatoid Factor / analysis
  • Skin / pathology*

Substances

  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibodies, Antinuclear
  • Dapsone
  • Collagen
  • Rheumatoid Factor
  • Prednisolone