Manufacture of strontium-82/rubidium-82 generators and quality control of rubidium-82 chloride for myocardial perfusion imaging in patients using positron emission tomography

Appl Radiat Isot. 1999 Jun;50(6):1015-23. doi: 10.1016/s0969-8043(98)00170-5.

Abstract

We describe a protocol to manufacture 82Sr/82Rb generators and 82RbCl for myocardial imaging with PET. The generators are manufactured in 3 stages: (1) preparation of a tin oxide column, (2) leak test of the generator column and (3) loading of the generator with 82Sr. The generators produced sterile and non-pyrogenic 82RbCl for i.v. injection. No significant 82Sr/85Sr breakthroughs were observed after elution with 20 1 of saline. The automated system delivered human doses of 82RbCl accurately.

MeSH terms

  • Chlorides / standards*
  • Chlorides / therapeutic use
  • Coronary Disease / diagnostic imaging
  • Heart / diagnostic imaging*
  • Humans
  • Quality Control
  • Radiation Protection
  • Radionuclide Generators*
  • Rubidium / standards*
  • Rubidium / therapeutic use
  • Rubidium Radioisotopes*
  • Strontium Radioisotopes*
  • Tomography, Emission-Computed* / instrumentation
  • Tomography, Emission-Computed* / methods

Substances

  • Chlorides
  • Rubidium Radioisotopes
  • Strontium Radioisotopes
  • Rubidium
  • rubidium chloride