Abstract
RIP3 is a novel gene product containing a N-terminal kinase domain that shares extensive homology with the corresponding domain in RIP (receptor-interacting protein) and RIP2. Unlike RIP, which has a C-terminal death domain, and RIP2, which has a C-terminal caspase activation and recruitment domain, RIP3 has a unique C terminus. RIP3 binds RIP through its unique C-terminal segment and by virtue of this interaction is recruited to the tumor necrosis factor (TNF) receptor-1 signaling complex. Previous studies have shown that RIP mediates TNF-induced activation of the anti-apoptotic NF-kappaB pathway. RIP3, however, attenuates both RIP and TNF receptor-1-induced NF-kappaB activation. Overexpression studies revealed RIP3 to be a potent inducer of apoptosis, capable of selectively binding to large prodomain initiator caspases.
MeSH terms
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Amino Acid Sequence
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Antigens, CD / metabolism
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Apoptosis*
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Caspases / metabolism
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Cloning, Molecular
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Humans
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Molecular Sequence Data
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NF-kappa B / metabolism
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Protein Binding
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Protein Kinases / genetics
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Protein Kinases / metabolism*
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Protein Serine-Threonine Kinases
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Proteins / metabolism
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Receptor-Interacting Protein Serine-Threonine Kinase 2
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Receptor-Interacting Protein Serine-Threonine Kinases
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Receptors, Tumor Necrosis Factor / metabolism
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Receptors, Tumor Necrosis Factor, Type I
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Recombinant Proteins / metabolism
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Sequence Analysis
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Sequence Homology, Amino Acid
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Signal Transduction
Substances
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Antigens, CD
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NF-kappa B
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Proteins
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Type I
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Recombinant Proteins
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Protein Kinases
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Protein Serine-Threonine Kinases
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RIPK1 protein, human
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RIPK2 protein, human
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RIPK3 protein, human
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Receptor-Interacting Protein Serine-Threonine Kinase 2
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Receptor-Interacting Protein Serine-Threonine Kinases
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Caspases
Associated data
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GENBANK/AA227673
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GENBANK/AI082587
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GENBANK/AI394293