I-123 MIBG cardiac imaging in diabetic neuropathy before and after epalrestat therapy

Clin Nucl Med. 1999 Jun;24(6):418-20. doi: 10.1097/00003072-199906000-00008.

Abstract

I-123 metaiodobenzylguanidine (MIBG) scintigraphy is a new method to evaluate cardiac sympathetic nerve disturbance in patients with diabetes mellitus. Epalrestat specifically inhibits aldose reductase and improves diabetic neuropathy. The authors report a case of improvement in cardiac sympathetic dysfunction using MIBG scintigraphy with epalrestat therapy. In this case, epalrestat effectively reversed diabetic neuropathy, and MIBG scintigraphy was useful to evaluate the effect of epalrestat.

Publication types

  • Case Reports

MeSH terms

  • 3-Iodobenzylguanidine*
  • Adult
  • Aldehyde Reductase / antagonists & inhibitors*
  • Autonomic Nervous System Diseases / diagnostic imaging*
  • Diabetic Neuropathies / diagnostic imaging*
  • Diabetic Neuropathies / drug therapy
  • Enzyme Inhibitors / therapeutic use*
  • Heart / diagnostic imaging*
  • Heart / innervation
  • Humans
  • Male
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Rhodanine / analogs & derivatives*
  • Rhodanine / therapeutic use
  • Thiazolidines

Substances

  • Enzyme Inhibitors
  • Radiopharmaceuticals
  • Thiazolidines
  • 3-Iodobenzylguanidine
  • epalrestat
  • Rhodanine
  • Aldehyde Reductase