[Visceral leishmaniasis associated with Wegener disease. Use of lipid complex amphotericin B and liposomal amphotericin B]

Presse Med. 1999 May 15;28(18):959-61.
[Article in French]

Abstract

Background: Leishmaniasis in a patient with Wegenerís disease raises the problem of amphotericin toxicity further compromising the pre-existing renal disorder.

Case report: An anemic patient treated for Wegenerís disease developed visceral leishmaniasis. This renal failure patient was treated with lipid complex amphotericin B and liposomal amphotericin B. We report outcome at 10 months follow-up.

Discussion: The new formulations of amphotericin B allow effective treatment of visceral leishmaniasis in renal failure patients. Long-lasting results are probably favored by the interruption of immuno-suppressive therapy.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Acute Kidney Injury / drug therapy
  • Aged
  • Amphotericin B / adverse effects
  • Amphotericin B / therapeutic use*
  • Anemia / drug therapy
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use
  • Female
  • Follow-Up Studies
  • Granulomatosis with Polyangiitis / complications
  • Granulomatosis with Polyangiitis / drug therapy*
  • Humans
  • Leishmaniasis, Visceral / chemically induced*
  • Liposomes
  • Male
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Liposomes
  • Amphotericin B