Impact of localized radiotherapy on blood immune cells counts and function in humans

C Belka; H Ottinger; E Kreuzfelder; M Weinmann; M Lindemann; A Lepple-Wienhues; W Budach; H Grosse-Wilde; M Bamberg

doi:10.1016/s0167-8140(98)00130-3

Impact of localized radiotherapy on blood immune cells counts and function in humans

Radiother Oncol. 1999 Feb;50(2):199-204. doi: 10.1016/s0167-8140(98)00130-3.

Authors

C Belka¹, H Ottinger, E Kreuzfelder, M Weinmann, M Lindemann, A Lepple-Wienhues, W Budach, H Grosse-Wilde, M Bamberg

Affiliation

¹ Department of Radiation Oncology, Eberhard Karls University Tübingen, Germany.

PMID: 10368044
DOI: 10.1016/s0167-8140(98)00130-3

Abstract

Immune cells subsets were prospectively analyzed after localized radiotherapy (LRT). LRT reduced the levels of all lymphocyte subsets, with B-cells and naive T-cells being most sensitive. Lymphocyte function was suppressed, but still within the normal range. Rapid recovery of cytotoxic T-cells/natural killer cells after LRT and the functional suppression within normal levels explains the low incidence of infections after LRT.

Publication types

Comparative Study

MeSH terms

Adolescent
Adult
B-Lymphocytes / immunology*
B-Lymphocytes / radiation effects
Humans
Lymphocyte Activation / immunology
Lymphocyte Activation / radiation effects
Lymphocyte Count / radiation effects
Lymphocyte Subsets / immunology*
Lymphocyte Subsets / radiation effects
Male
Middle Aged
Orchiectomy
Prospective Studies
Seminoma / immunology
Seminoma / radiotherapy*
Seminoma / surgery
T-Lymphocytes / immunology*
T-Lymphocytes / radiation effects
Testicular Neoplasms / immunology
Testicular Neoplasms / radiotherapy*
Testicular Neoplasms / surgery