Objective: To study the copy number of chromsomes 7,17 and Y in lung carcinomas.
Methods: Fluorescence in situ hybridization (FISH) was used to detect the number of above mentioned chromosomes on the touch smears of 17 cases of lung carcinoma (adenocarcinoma and squamous cell carcinoma).
Results: Triploid chromosome 7 FISH signals were found in 31.73% of the tumor nuclei, dipoid chromosome 17 FISH signals in 43.00% and monoploid chromosome Y FISH signals in 58.04% of these nuclei.
Conclusions: The number of chromosome 7 was obviously increased in both lung adenocarcinoma and squamous cell carcinoma, and the rate of trisomy 7 was the highest. In addition, there is a significant difference in the distribution of chromosome 7 ploidy between lung adenocarcinoma and squamous cell carcinoma.