T cell co-stimulatory molecules other than CD28

Curr Opin Immunol. 1999 Jun;11(3):286-93. doi: 10.1016/s0952-7915(99)80046-6.

Abstract

CD28 is the primary co-stimulatory receptor for inducing high-level IL-2 production and survival of naïve CD4(+) T cells. While no other cell surface receptor can be considered fully redundant with CD28, recent developments suggest that additional co-stimulatory pathways have preferential effects at different stages of T cell activation, on different subsets of T cells or contribute to the development of different effector functions.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD / metabolism
  • CD24 Antigen
  • CD28 Antigens / metabolism*
  • Cell Adhesion Molecules / metabolism
  • Humans
  • Intercellular Adhesion Molecule-1 / metabolism
  • Lymphocyte Activation
  • Lymphocyte Function-Associated Antigen-1 / metabolism
  • Membrane Glycoproteins*
  • Receptors, Nerve Growth Factor / metabolism
  • Receptors, OX40
  • Receptors, Tumor Necrosis Factor / metabolism
  • Signal Transduction
  • T-Lymphocytes / immunology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / metabolism
  • Tumor Necrosis Factor Receptor Superfamily, Member 9

Substances

  • Antigens, CD
  • CD24 Antigen
  • CD24 protein, human
  • CD28 Antigens
  • Cell Adhesion Molecules
  • Lymphocyte Function-Associated Antigen-1
  • Membrane Glycoproteins
  • Receptors, Nerve Growth Factor
  • Receptors, OX40
  • Receptors, Tumor Necrosis Factor
  • TNFRSF4 protein, human
  • TNFRSF9 protein, human
  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  • Tumor Necrosis Factor Receptor Superfamily, Member 9
  • Intercellular Adhesion Molecule-1