Abstract
Successful xenotransplantation depends on many factors, one being the interactions of cross-species adhesion molecule-ligand pairs. Depending on the approach used to facilitate xenotransplantation, these interactions can play differing roles. Here, André Simon, Anthony Warrens and Megan Sykes review the existing information on pig-to-human adhesive interactions and its implication for different approaches to pig-to-human xenotransplantation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Adhesion / genetics
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Cell Adhesion / immunology*
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Cell Adhesion Molecules / genetics
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Cell Adhesion Molecules / immunology
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Graft Rejection / genetics
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Graft Rejection / immunology
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Graft Rejection / prevention & control
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Humans
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Immune Tolerance
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Immunosuppression Therapy
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Integrins / genetics
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Integrins / immunology
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Ligands
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Swine
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Tissue Donors
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Transplantation, Heterologous / adverse effects
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Transplantation, Heterologous / immunology*
Substances
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Cell Adhesion Molecules
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Integrins
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Ligands