Seeking ligands for lonely orphan receptors

Science. 1999 May 21;284(5418):1285-6. doi: 10.1126/science.284.5418.1285.
No abstract available

Publication types

  • Comment

MeSH terms

  • Animals
  • Bile Acids and Salts / biosynthesis
  • Chenodeoxycholic Acid / metabolism*
  • Cholesterol / metabolism*
  • Cholesterol 7-alpha-Hydroxylase / biosynthesis
  • Cholesterol 7-alpha-Hydroxylase / genetics*
  • Cholic Acid / metabolism
  • Cytochrome P-450 Enzyme System / metabolism
  • Cytochrome P450 Family 7
  • DNA-Binding Proteins / metabolism*
  • Fatty Acids / metabolism
  • Gene Expression Regulation, Enzymologic
  • Homeostasis
  • Humans
  • Ligands
  • Liver / metabolism
  • Liver X Receptors
  • Mice
  • Orphan Nuclear Receptors
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Steroid Hydroxylases / metabolism
  • Transcription Factors / metabolism*
  • Transcription, Genetic

Substances

  • Bile Acids and Salts
  • DNA-Binding Proteins
  • Fatty Acids
  • Ligands
  • Liver X Receptors
  • Orphan Nuclear Receptors
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • farnesoid X-activated receptor
  • Chenodeoxycholic Acid
  • Cytochrome P-450 Enzyme System
  • Cholesterol
  • Steroid Hydroxylases
  • oxysterol 7-alpha-hydroxylase
  • Cholesterol 7-alpha-Hydroxylase
  • Cytochrome P450 Family 7
  • CYP7B1 protein, human
  • Cholic Acid