Incidence and outcome of a 10-fold indomethacin overdose in premature infants

J Pediatr. 1999 Jul;135(1):105-7. doi: 10.1016/s0022-3476(99)70337-9.

Abstract

We reviewed the incidence and morbidity of a 10-fold medication error among all premature infants treated with indomethacin. We detected 4 incidents among 1059 indomethacin doses given to infants weighing less than 1000 g. None of the infants had intracranial hemorrhage, necrotizing enterocolitis, or significant deterioration of renal function.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / poisoning*
  • Bronchopulmonary Dysplasia / chemically induced
  • Cerebral Hemorrhage / chemically induced
  • Ductus Arteriosus, Patent / drug therapy*
  • Enterocolitis, Necrotizing / chemically induced
  • Female
  • Humans
  • Indomethacin / poisoning*
  • Infant, Newborn
  • Infant, Premature, Diseases / drug therapy*
  • Male
  • Medication Errors / statistics & numerical data*
  • Retrospective Studies

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Indomethacin