Abstract
The oxidative dimerization of ferulic acid has been carried out using horse-radish peroxidase as catalyst to give a dihydrobenzofuran neolignan (1), the structure of which was elucidated as (2SR,3RS)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-n-buto xycarbonyl-5-(2E-carboxyethenyl)-7-methoxybenzofuran by spectroscopic analyses. This compound showed more potent cytotoxicity against several tumor cell lines than the starting material.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylates / chemical synthesis*
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Acrylates / pharmacology*
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Benzofurans / chemical synthesis*
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Benzofurans / pharmacology*
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Coumaric Acids / pharmacology*
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Drug Evaluation
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Free Radical Scavengers / pharmacology*
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Horseradish Peroxidase / chemistry*
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Humans
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Mice
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Oxidation-Reduction
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Tumor Cells, Cultured
Substances
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Acrylates
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Antineoplastic Agents
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Benzofurans
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Coumaric Acids
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Free Radical Scavengers
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dogwalker1
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ferulic acid
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Horseradish Peroxidase