Abstract
We investigated the expression of apoptosis-related factors, p53, Bax, Bcl-2, and spontaneous apoptosis in 57 cases of oral and oropharyngeal squamous cell carcinoma (SCC) by immunochemical staining and ApopTag kit. Positive expression of Bax was inversely associated with advanced tumor stage (P = 0.0225), lymph node metastasis (P = 0.0225), clinical stage (P = 0.0083) and poor prognosis (P = 0.0478). Positive expression of p53 was related to poor prognosis (P = 0.0445) and was associated with negative expression of Bax (P = 0.0439). The apoptosis index did not correlate with clinical outcome. These results suggest that abnormality of Bax expression plays an important role in tumor progression in oral and oropharyngeal SCC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis
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Carcinoma, Squamous Cell / diagnosis*
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Carcinoma, Squamous Cell / metabolism*
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / pathology
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Humans
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Immunohistochemistry
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Lymphatic Metastasis / diagnosis
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Mouth Neoplasms / diagnosis*
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Mouth Neoplasms / metabolism*
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Mouth Neoplasms / mortality
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Mouth Neoplasms / pathology
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Oropharyngeal Neoplasms / diagnosis*
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Oropharyngeal Neoplasms / metabolism*
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Oropharyngeal Neoplasms / mortality
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Oropharyngeal Neoplasms / pathology
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Prognosis
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Proportional Hazards Models
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Proto-Oncogene Proteins / biosynthesis*
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Survival Rate
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Tumor Suppressor Protein p53 / metabolism
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bcl-2-Associated X Protein
Substances
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BAX protein, human
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Tumor Suppressor Protein p53
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bcl-2-Associated X Protein