Abstract
The synthesis of oligodeoxyribonucleotides incorporating 7-deoxycholic acid conjugated at C5 of dU is described. When used as third strand, these form oligonucleotide triplexes with higher stability compared to unmodified controls at physiological pH.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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DNA / chemistry*
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DNA / metabolism*
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Dose-Response Relationship, Radiation
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Molecular Sequence Data
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Nucleic Acid Conformation
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Oligonucleotides / chemistry*
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Oligonucleotides / radiation effects
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Steroids / chemistry*
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Steroids / metabolism*
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Temperature
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Ultraviolet Rays
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Uracil / chemistry
Substances
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Oligonucleotides
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Steroids
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Uracil
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DNA