CMT-8/clodronate combination therapy synergistically inhibits alveolar bone loss in LPS-induced periodontitis

Ann N Y Acad Sci. 1999 Jun 30:878:671-4. doi: 10.1111/j.1749-6632.1999.tb07758.x.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alveolar Bone Loss / prevention & control*
  • Animals
  • Clodronic Acid / therapeutic use*
  • Collagenases / metabolism
  • Drug Synergism
  • Drug Therapy, Combination
  • Gelatinases / metabolism
  • Gingiva / enzymology
  • Lipopolysaccharides / toxicity*
  • Male
  • Periodontitis / chemically induced
  • Periodontitis / complications
  • Periodontitis / physiopathology*
  • Protease Inhibitors / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley
  • Tetracyclines / therapeutic use*
  • Tooth Mobility / prevention & control

Substances

  • Lipopolysaccharides
  • Protease Inhibitors
  • Tetracyclines
  • tetracycline CMT-8
  • Clodronic Acid
  • Collagenases
  • Gelatinases