Identification of the TIMP-2 binding site on the gelatinase A hemopexin C-domain by site-directed mutagenesis and the yeast two-hybrid system

Ann N Y Acad Sci. 1999 Jun 30:878:747-53. doi: 10.1111/j.1749-6632.1999.tb07780.x.
No abstract available

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Cloning, Molecular
  • Gelatinases / chemistry*
  • Gelatinases / metabolism*
  • Hemopexin / chemistry*
  • Humans
  • Kinetics
  • Matrix Metalloproteinase 2
  • Metalloendopeptidases / chemistry*
  • Metalloendopeptidases / metabolism*
  • Models, Molecular
  • Mutagenesis, Site-Directed
  • Protein Conformation
  • Recombinant Proteins / chemistry
  • Recombinant Proteins / metabolism
  • Saccharomyces cerevisiae
  • Tissue Inhibitor of Metalloproteinase-2 / metabolism*

Substances

  • Recombinant Proteins
  • Tissue Inhibitor of Metalloproteinase-2
  • Hemopexin
  • Gelatinases
  • Metalloendopeptidases
  • Matrix Metalloproteinase 2