[Paraneoplastic Cushing's syndrome and small cell bronchial carcinoma]

B Mennecier; L Moreau; B Goichot; G Pauli; E Quoix

[Paraneoplastic Cushing's syndrome and small cell bronchial carcinoma]

Rev Pneumol Clin. 1999 Apr;55(2):77-80.

[Article in French]

Authors

B Mennecier¹, L Moreau, B Goichot, G Pauli, E Quoix

Affiliation

¹ Pavillon Laënnec, Hôpital Civil, Strasbourg.

PMID: 10418050

Abstract

Approximately 30% of small-cell bronchogenic cancers are associated with hypersecretion of ACTH. However, in most cases, there is no clinical expression. When a paraneoplastic Cushing syndrome occurs, it is an independent factor of poor prognosis. Management is extremely complex. Treatment must be based on high dose inhibitors prior to chemotherapy. Opportunistic infections, often fungal infections, are the main complications, even outside periods of aplasia, and cause significantly earlier mortality.

Publication types

Case Reports
Review

MeSH terms

Adrenocorticotropic Hormone / blood
Adrenocorticotropic Hormone / metabolism
Carcinoma, Bronchogenic / complications*
Carcinoma, Bronchogenic / mortality
Carcinoma, Small Cell / complications*
Carcinoma, Small Cell / mortality
Cushing Syndrome / drug therapy
Cushing Syndrome / etiology*
Cushing Syndrome / physiopathology
Female
Humans
Lung Neoplasms / complications*
Lung Neoplasms / mortality
Male
Middle Aged
Paraneoplastic Syndromes* / mortality
Prognosis
Retrospective Studies
Time Factors

Substances

Adrenocorticotropic Hormone