[Antiphospholipid syndrome]

Rev Med Univ Navarra. 1998 Oct-Dec;42(4):194-207.
[Article in Spanish]

Abstract

Antiphospholipid syndrome is a well-defined clinical and serological entity characterized by arterial and/or venous thrombosis, recurrent abortion and thrombocytopenia. Anticardiolipin antibodies and lupus anticoagulant are autoantibodies directed against negatively charged phospholipids, which represent the serologic criteria for the diagnosis of the antiphospholipid syndrome. In this review the pathogenic mechanisms of anticardiolipin antibodies, their clinical findings and the current therapeutical strategies are discussed.

Publication types

  • Review

MeSH terms

  • Abortion, Habitual / etiology
  • Abortion, Habitual / prevention & control
  • Animals
  • Antibodies, Antiphospholipid / immunology
  • Anticoagulants / therapeutic use
  • Antiphospholipid Syndrome* / diagnosis
  • Antiphospholipid Syndrome* / etiology
  • Antiphospholipid Syndrome* / immunology
  • Antiphospholipid Syndrome* / therapy
  • Autoimmune Diseases* / diagnosis
  • Autoimmune Diseases* / etiology
  • Autoimmune Diseases* / immunology
  • Autoimmune Diseases* / therapy
  • Blood Component Transfusion
  • Connective Tissue Diseases / complications
  • Female
  • Genetic Predisposition to Disease
  • Glycoproteins / immunology
  • HLA-D Antigens / genetics
  • HLA-D Antigens / immunology
  • Immunosuppressive Agents / therapeutic use
  • Infections / complications
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred MRL lpr
  • Molecular Mimicry
  • Neoplasms / complications
  • Pregnancy
  • Thrombocytopenia / drug therapy
  • Thrombocytopenia / etiology
  • Thrombolytic Therapy
  • Thrombophilia / drug therapy
  • Thrombophilia / etiology
  • beta 2-Glycoprotein I

Substances

  • Antibodies, Antiphospholipid
  • Anticoagulants
  • Glycoproteins
  • HLA-D Antigens
  • Immunosuppressive Agents
  • beta 2-Glycoprotein I