Inhibition of cathepsin D by tripeptides containing statine analogs

Biochem Pharmacol. 1999 Jul 15;58(2):329-33. doi: 10.1016/s0006-2952(99)00103-3.

Abstract

Various analogs of statine, a remarkable amino acid component of the protease inhibitor pepstatine, were synthesized and evaluated as tripeptide derivatives for their activity against cathepsin D and HIV-1 protease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Amino Acids / pharmacology*
  • Cathepsin D / antagonists & inhibitors*
  • HIV Protease Inhibitors / chemistry
  • HIV Protease Inhibitors / pharmacology
  • Humans
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology*
  • Pepstatins / chemistry
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology*
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Amino Acids
  • HIV Protease Inhibitors
  • Oligopeptides
  • Pepstatins
  • Protease Inhibitors
  • Streptomyces pepsin inhibitor
  • Cathepsin D
  • pepstatin
  • statine